Absolutely not.
Even if the trunk is empty, along with the glove box: I've had vehicles stolen from my driveway when I was home, in one instance it meant that the baby's stroller, car seat, as well as half of my husbands cordless tools were lost (because they were in the trunk when the car was stolen).
Car theft has become such an issue, the city now has 'bait cars' in it's anti-theft repetoire.